A photographer (Rachel Weisz) returns to the community that shunned her decades earlier for an attraction to a childhood friend (Rachel McAdams). Passions reignite as they explore the boundaries of faith and sexuality.

When filmmaker Will Lautzenheiser’s limbs are amputated, his life is derailed and he turns to stand-up comedy as therapy. Meanwhile, a world-famous medical team is performing transplants that restore bodies to unprecedented levels. Despite grave risks, Will agrees to undergo an experimental double-arm transplant in the hope of reclaiming his independence.