A comedic clash of cultures unfolds as David and his boyfriend Khaled plan to marry, facing opposition from their families. David's mother is Islamophobic, and Khaled's father is homophobic. Complications arise when a young woman brings news that tests their relationship.

Perhaps Italy’s first romantic comedy with a female couple at the center, ME, MYSELF AND HER stars Sabrina Ferilli as happily out restaurateur Marina and Margherita Buy (from Tognazzi’s previous A FIVE STAR LIFE) as Federica, a previously married architect whose fear of what others might think gives her pause about the relationship. With a light tone, this warm look at the everyday struggles of two people to build a life together strikes a universal chord.